Augmentation and Evaluation of an Olive Oil Based Polyherbal Combination against Diabetic Cardiomyopathy in Experimental Model of Rodents
نویسندگان
چکیده
Diabetes mellitus is a metabolic disorder that prima facie cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes cardiomyopathy. Cardiomyopathy refers to diseases of the heart muscle, where muscle becomes enlarged, thick, or rigid. As cardiomyopathy worsens, weaker unable conduct right amount blood through body maintain normal electrical rhythm. This can lead failure arrhythmias. Chronic one instigating factors behind etiology this cardiac complication. Type-II impaired glucose metabolism increases dependence diabetic on fatty acid oxidation meet its functional demands, resulting in mitochondrial uncoupling, glucotoxicity, lipotoxicity initially subclinical dysfunction finally gives way failure. The increasing population disorders ironically decreasing trend newer medications counter leave us at crossroads pharmacological management Keeping view, present study proclaims newly developed polyherbal combination (PHC) three herbs, namely Tinospora cordifolia, Withania somnifera Boerhavia diffusa based olive oil administered fixed dose (PHC-6 PHC-10) screen cardioprotective potential against well-established experimental model herbs mentioned have been known traditional literature their antidiabetic roles, hence they became obvious choice. follows an proposed by Reed et al., capacity β-cell unobtrusively impeded without totally compromising insulin release, bringing about moderate disability resilience. Various sophisticated parameters, intraventricular septum thickness hearts, Western blot α/β- MHC monoclonal antibody (Ab), pyruvate dehydrogenase (PDH) activity, medium chain acyl coenzyme (MCAD) enzyme, etc. showed promising results treatment PHC significantly (*** p < 0.001 **** 0.0001) prevented symptoms subsequent groups when compared disease control group.
منابع مشابه
an application of equilibrium model for crude oil tanker ships insurance futures in iran
با توجه به تحریم های بین المملی علیه صنعت بیمه ایران امکان استفاده از بازارهای بین المملی بیمه ای برای نفتکش های ایرانی وجود ندارد. از طرفی از آنجایی که یکی از نوآوری های اخیر استفاده از بازارهای مالی به منظور ریسک های فاجعه آمیز می باشد. از اینرو در این پایان نامه سعی شده است با استفاده از این نوآوری ها با طراحی اوراق اختیارات راهی نو جهت بیمه گردن نفت کش های ایرانی ارائه نمود. از آنجایی که بر...
simulation and experimental studies for prediction mineral scale formation in oil field during mixing of injection and formation water
abstract: mineral scaling in oil and gas production equipment is one of the most important problem that occurs while water injection and it has been recognized to be a major operational problem. the incompatibility between injected and formation waters may result in inorganic scale precipitation in the equipment and reservoir and then reduction of oil production rate and water injection rate. ...
an investigation into iranian teachers consistency and bias in evaluation of students writings
while performance-based language assessment has led to an increased authenticity and content validity in the practice of writing assessment, the reliability of ratings has become a major issue. research findings have shown different reactions by native english speaker (nes) and non-native english speaker (nns) teachers to students’ writings. the focus of this study is on investigating whether i...
cost benefits of rehabilitation after acute coronary syndrome in iran; using an epidemiological model
چکیده ندارد.
development and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetology
سال: 2022
ISSN: ['2673-4540']
DOI: https://doi.org/10.3390/diabetology3040043