Augmentation and Evaluation of an Olive Oil Based Polyherbal Combination against Diabetic Cardiomyopathy in Experimental Model of Rodents

نویسندگان

چکیده

Diabetes mellitus is a metabolic disorder that prima facie cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes cardiomyopathy. Cardiomyopathy refers to diseases of the heart muscle, where muscle becomes enlarged, thick, or rigid. As cardiomyopathy worsens, weaker unable conduct right amount blood through body maintain normal electrical rhythm. This can lead failure arrhythmias. Chronic one instigating factors behind etiology this cardiac complication. Type-II impaired glucose metabolism increases dependence diabetic on fatty acid oxidation meet its functional demands, resulting in mitochondrial uncoupling, glucotoxicity, lipotoxicity initially subclinical dysfunction finally gives way failure. The increasing population disorders ironically decreasing trend newer medications counter leave us at crossroads pharmacological management Keeping view, present study proclaims newly developed polyherbal combination (PHC) three herbs, namely Tinospora cordifolia, Withania somnifera Boerhavia diffusa based olive oil administered fixed dose (PHC-6 PHC-10) screen cardioprotective potential against well-established experimental model herbs mentioned have been known traditional literature their antidiabetic roles, hence they became obvious choice. follows an proposed by Reed et al., capacity β-cell unobtrusively impeded without totally compromising insulin release, bringing about moderate disability resilience. Various sophisticated parameters, intraventricular septum thickness hearts, Western blot α/β- MHC monoclonal antibody (Ab), pyruvate dehydrogenase (PDH) activity, medium chain acyl coenzyme (MCAD) enzyme, etc. showed promising results treatment PHC significantly (*** p < 0.001 **** 0.0001) prevented symptoms subsequent groups when compared disease control group.

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ژورنال

عنوان ژورنال: Diabetology

سال: 2022

ISSN: ['2673-4540']

DOI: https://doi.org/10.3390/diabetology3040043